Warfarin Pharmacogenetics

Pharmacogenetics is a section of medical genetics and pharmacology that studies genetically caused individual responses to drugs.

The basic concept of pharmacogenetics consists of various human sensitivity to therapy and effect of certain drugs, depending on genetic characteristics (polymorphic variants of the genotype). The polymorphic nature of many enzymes responsible for their penetration and removal from cells that participate in the metabolism of drugs, and transporters has been established.

Warfarin, an anticoagulant of indirect action, is world’s most widely prescribed drug. This anticoagulant was synthesized back in the 40’s of the last century. Warfarin owes its popularity to, first, high efficacy, and secondly, ease of use.

The most important genes that determine individual response to warfarin therapy are CYP2C9, CYP4F2 and VKORC1. Based on genetic test results, a doctor or clinician can estimate an expected saturated and therapeutic dose of warfarin for each individual patient.

Warfarin Pharmacogenetics REAL-TIME PCR genotyping Kit is intended for detection and allelic discrimination of genetic polymorphisms associated with an individual’s response to Coumarin (Warfarin) therapy. The results of the genetic test can be used for assessment of effective and safe dosage of Coumarin (Warfarin).

Sample: peripheral blood

DNA extraction: PREP-GS-GENETICS and PREP-RAPID-GENETICS kits

Certification: CE/IVD