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Hemostasis F2, F5 mutations

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Multifactorial disorders or diseases with hereditary predisposition are caused by interaction of certain combinations of alleles of different loci and specific environmental factors. Multifactorial diseases include hypertension, stroke, thrombosis, most cardiovascular diseases and tumors.

Multifactorial disorders or diseases with hereditary predisposition are caused by interaction of certain combinations of alleles of different loci and specific environmental factors. Multifactorial diseases include hypertension, stroke, thrombosis, most cardiovascular diseases and tumors.

Thrombophilia is the state of the blood system, which manifests itself in hemostasis disorder and has a propensity to develop recurrent vascular thrombosis (mostly venous) of different localization and often occurring in association with pregnancy, after surgery, injury or physical overstrain. The disease is caused by genetic (in 30-50 % of thrombotic conditions) or acquired disorders of blood cells, as well as defects in the blood coagulation system.

Genetic predisposition to thrombophilia can occur through genetic defects in both coagulation and anticoagulation (anticoagulant and fibrinolytic) blood systems in which there is a tendency to develop thrombosis.

Genetic analysis allows detecting the gene polymorphisms of factors of the hemostasis system, which lead to abnormal synthesis of the factors or functional activity disorder. This permits to assess the risks of development of cardiovascular disease and obstetrical complications, thromboembolism, venous and arterial thrombosis. Screening of genetic features of thrombophilia helps to early identify patients at risk and make appropriate adjustments in their management tactics.

Hemostasis F2, F5 mutations REAL-TIME PCR Genotyping Kit is intended for detection and allelic discrimination of the genetic polymorphisms associated with risk of health complications provided by hormonal contraception use or in case of passing by hormonal replacement therapy.

Sample: peripheral blood

DNA extraction: PREP-GS-GENETICS and PREP-RAPID-GENETICS kits

Certification: CE/IVD

Типы детекции:
Real-time format is designed to detect PCR results during amplification with the help of detecting amplifiers (in real time).
RT