Thrombophilia Susceptibility

Multifactorial disorders or diseases with hereditary predisposition are caused by interaction of certain combinations of alleles of different loci and specific environmental factors. Multifactorial diseases include hypertension, stroke, thrombosis, most cardiovascular diseases and tumors.

Thrombophilia is the state of the blood system, which manifests itself in hemostasis disorder and has a propensity to develop recurrent vascular thrombosis (mostly venous) of different localization and often occurring in association with pregnancy, after surgery, injury or physical overstrain. The disease is caused by genetic (in 30-50 % of thrombotic conditions) or acquired disorders of blood cells, as well as defects in the blood coagulation system.

Genetic predisposition to thrombophilia can occur through genetic defects in both coagulation and anticoagulation (anticoagulant and fibrinolytic) blood systems in which there is a tendency to develop thrombosis.

Genetic analysis allows detecting the gene polymorphisms of factors of the hemostasis system, which lead to abnormal synthesis of the factors or functional activity disorder. This permits to assess the risks of development of cardiovascular disease and obstetrical complications, thromboembolism, venous and arterial thrombosis. Screening of genetic features of thrombophilia helps to early identify patients at risk and make appropriate adjustments in their management tactics.

Thrombophilia Susceptibility REAL-TIME PCR Genotyping Kit and Hypertension Susceptibility REAL-TIME PCR Genotyping Kit allow detection of a range of genetic polymorphisms associated with cardiovascular disorders. The employed Real-time PCR method discriminates alleles thus providing genotype information that helps to evaluate the genetic background of a current clinical condition, or to estimate odds of disease development.

Thrombophilia Susceptibility REAL-TIME PCR Genotyping Kit is intended for detection and allelic discrimination of genetic polymorphisms associated with inherited susceptibility to thrombosis (OMIM #188050).

Sample: peripheral blood

DNA extraction: PREP-GS-GENETICS and PREP-RAPID-GENETICS kits

Certification: CE/IVD