Hemostasis F2, F5 mutations
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Multifactorial disorders or diseases with hereditary predisposition are caused by interaction of certain combinations of alleles of different loci and specific environmental factors. Multifactorial diseases include hypertension, stroke, thrombosis, most cardiovascular diseases and tumors.
Multifactorial disorders or diseases with hereditary predisposition are caused by interaction of certain combinations of alleles of different loci and specific environmental factors. Multifactorial diseases include hypertension, stroke, thrombosis, most cardiovascular diseases and tumors.
Thrombophilia is the state of the blood system, which manifests itself in hemostasis disorder and has a propensity to develop recurrent vascular thrombosis (mostly venous) of different localization and often occurring in association with pregnancy, after surgery, injury or physical overstrain. The disease is caused by genetic (in 30-50 % of thrombotic conditions) or acquired disorders of blood cells, as well as defects in the blood coagulation system.
Genetic predisposition to thrombophilia can occur through genetic defects in both coagulation and anticoagulation (anticoagulant and fibrinolytic) blood systems in which there is a tendency to develop thrombosis.
Genetic analysis allows detecting the gene polymorphisms of factors of the hemostasis system, which lead to abnormal synthesis of the factors or functional activity disorder. This permits to assess the risks of development of cardiovascular disease and obstetrical complications, thromboembolism, venous and arterial thrombosis. Screening of genetic features of thrombophilia helps to early identify patients at risk and make appropriate adjustments in their management tactics.
The Hemostasis F2, F5 mutations REAL-TIME PCR Genotyping Kit is an in vitro Nucleic Acid Test (NAT) – human genotyping-based product.
The Hemostasis F2, F5 mutations REAL-TIME PCR Genotyping Kit is designed to detect polymorphisms of genes associated with the risk of dyscrasia (bleeding, thrombosis): F2 (prothrombin, coagulation factor II, 20210 G>A); F5 (coagulation factor V Leiden, 1691 G>A) by real-time PCR in human biological material.
The Hemostasis F2, F5 mutations REAL-TIME PCR Genotyping Kit is intended for research and diagnostic applications.
Certification: RU/IVD
| Sample | Whole peripheral blood, dry blood spots, buccal epithelium |
| NA extraction | PREP-RAPID-GENETICS, PREP-GS-GENETICS, PREP-CITO DBS, PREP-MB MAX, PREP-OPTIMA MAX |
| Sensitivity | 1,0 ng per amplification tube |
| Storage requirements | +2...+8 °C |
| Except of minus part of the kit | -18…-22 °С |
| Shelf life | 12 months |
|
Detection instruments |
Number of tests |
Tubes(ml)/ Strips |
Product number |
|
48 |
not pre-aliquoted |
R1-H959-N3/4EU |
