Hypertension Susceptibility

Multifactorial disorders or diseases with hereditary predisposition are caused by interaction of certain combinations of alleles of different loci and specific environmental factors. Multifactorial diseases include hypertension, stroke, thrombosis, most cardiovascular diseases and tumors.

Hypertension is a set of conditions that are associated with long increase in hydrostatic pressure in the systemic circulation arteries. Hypertension is the most common disease among the adult population in developed countries.

Detection of genetic polymorphisms in the genes of the key regulation factors of the cardiovascular system, particularly associated with the functioning of the renin-angiotensin system (RAS), becomes the most urgent task.

Indications for genetic analysis:

• Ischemic heart disease (IHD);

• Acute myocardial infarction;

• Stroke;

• Diabetic nephropathy;

• Venous thromboembolism;

• Placental function disorders;

• Microcirculation and vascular tone disorders;

•  Diabetes;

• Selection of drugs for hypertension;

• Smoking.

Thrombophilia Susceptibility REAL-TIME PCR Genotyping Kit and Hypertension Susceptibility REAL-TIME PCR Genotyping Kit allow detection of a range of genetic polymorphisms associated with cardiovascular disorders. The employed Real-time PCR method discriminates alleles thus providing genotype information that helps to evaluate the genetic background of a current clinical condition, or to estimate odds of disease development.

Hypertension Susceptibility REAL-TIME PCR Genotyping Kit is intended for detection and allelic discrimination of genetic polymorphisms associated with hypertension (OMIM #145500).

Sample: peripheral blood

DNA extraction: PREP-GS-GENETICS and PREP-RAPID-GENETICS kits

Certification: CE/IVD