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Folate Metabolism

The actual product may vary from the images shown on the website.

The “Genetics of metabolism” assay allows detection of a range of genetic polymorphisms associated with metabolic disorders. The employed Real-time PCR method discriminates alleles thus providing genotype information that aids in the evaluation of the genetic background of current clinical conditions or to estimate odds of disease development.

Folic acid (vitamin B9) is a water-soluble vitamin, required for the growth and development of the circulatory and immune systems. Folic acid deficiency can cause megaloblastic anemia in adults and can increase the risk of neural tube defects during pregnancy.

Analysis of polymorphisms in folate cycle genes enables to determine predisposition to the above-mentioned pathological processes and allows for timely initiation of a corrective therapy.

Indications for genetic analysis:

• Elevated homocysteine blood levels (hyperhomocysteinemia);

• Miscarriage, fetal death;

• Birth of a child with isolated defects of the neural tube, heart or urogenital tract;

• Planned preparation for pregnancy;

• Presence of IHD, hypertension, atherosclerosis or atherothrombosis;

• Thromboembolism;

• Antiphospholipid syndrome;

• Family history of cancer;

• Prescription of oral contraceptives and hormone replacement therapy;

• Chemotherapy.

Folate Metabolism REAL-TIME PCR Genotyping Kit is intended for detection and allelic discrimination of genetic polymorphisms associated with inherited risk of folate cycle impairment.

Sample: peripheral blood

DNA extraction: PREP-GS-GENETICS and PREP-RAPID-GENETICS kits

Certification: CE/IVD

Типы детекции:
Real-time format is designed to detect PCR results during amplification with the help of detecting amplifiers (in real time).
RT

Storage requirements

+2...+8° С

Except of minus part of the kit

-18 … -22° С

Shelf life

6 months

Detection instruments

Number of tests

Tubes(ml)/ Strips

Product number

DT instruments with 4 detection channels.

48

not pre-aliquoted

R1-H908-N3/4EU