Osteoporosis

Osteoporosis is a progressive systemic skeletal disease characterized by decrease in the density and impaired micro-architectonics of bone tissue. It is accompanied by reduced bone strength and high risk of fractures.

In some cases, despite the presence of normal bone mineral density when measured, there could be disorders in the microarchitectonics of bones that lead to increased fragility. This situation may lead to an underestimation of the risk of osteoporosis and dangerous fractures. In this regard, more and more attention is paid to detection of gene polymorphisms (SNP), associated with osteoporosis.

The Osteoporosis REAL-TIME PCR Genotyping Kit is intended for detection and allelic discrimination of genetic polymorphisms associated with inherited risk of osteoporosis and bones fractures.

Indications for genetic analysis:

• Osteoporosis, fragility and pathological fractures among close relatives;

• Endocrine disorders that lead to menstrual disorders, diseases of the digestive system, circulatory system, and others;

• Drugs (glucocorticoids);

• If there is non-genetic risk factors for osteoporosis: postmenopause, low weight, lack of exercise, frail body build, deficiency of 25-hydroxy vitamin D3, including alimentary, increased consumption of coffee, bad habits (alcohol, tobacco);

• Individual intolerance to lactose (milk products).

Sample: peripheral blood

DNA extraction: PREP-GS-GENETICS and PREP-RAPID-GENETICS kits

Certification: RUO