Warfarin Pharmacogenetics
The actual product may vary from the images shown on the website.
Pharmacogenetics is a section of medical genetics and pharmacology that studies genetically caused individual responses to drugs.
The basic concept of pharmacogenetics consists of various human sensitivity to therapy and effect of certain drugs, depending on genetic characteristics (polymorphic variants of the genotype). The polymorphic nature of many enzymes responsible for their penetration and removal from cells that participate in the metabolism of drugs, and transporters has been established.
Warfarin, an anticoagulant of indirect action, is world’s most widely prescribed drug. This anticoagulant was synthesized back in the 40’s of the last century. Warfarin owes its popularity to, first, high efficacy, and secondly, ease of use.
The most important genes that determine individual response to warfarin therapy are CYP2C9, CYP4F2 and VKORC1. Based on genetic test results, a doctor or clinician can estimate an expected saturated and therapeutic dose of warfarin for each individual patient.
The Warfarin Pharmacogenetics REAL-TIME PCR Genotyping Kit is an in vitro Nucleic Acid Test (NAT) – human genotyping-based product.
The Warfarin Pharmacogenetics REAL-TIME PCR Genotyping Kit is designed to detect and discriminate four genetic polymorphisms associated with warfarin anticoagulant resistance (OMIM #122700) by real-time PCR.
The Warfarin Pharmacogenetics REAL-TIME PCR Genotyping Kit is intended for research and diagnostic applications.
Certification: RU/IVD
| Sample | Peripheral blood |
| NA extraction | PREP-GS-GENETICS, PREP-RAPID-GENETICS |
| Sensitivity | 1 ng per amplification tube |
| Storage requirements | +2...+8 °C |
| Except of minus part of the kit | -18…-22° С |
| Shelf life | 12 months |
|
Detection instruments |
Number of tests |
Tubes(ml)/ Strips |
Product number |
|
DT instruments (DNA-Technology) |
48 |
not pre-aliquoted |
R1-H904-N3/4EU |
