Hypertension Susceptibility
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Multifactorial disorders or diseases with hereditary predisposition are caused by interaction of certain combinations of alleles of different loci and specific environmental factors. Multifactorial diseases include hypertension, stroke, thrombosis, most cardiovascular diseases and tumors.
Hypertension is a set of conditions that are associated with long increase in hydrostatic pressure in the systemic circulation arteries. Hypertension is the most common disease among the adult population in developed countries.
Detection of genetic polymorphisms in the genes of the key regulation factors of the cardiovascular system, particularly associated with the functioning of the renin-angiotensin system (RAS), becomes the most urgent task.
Indications for genetic analysis:
• Ischemic heart disease (IHD);
• Acute myocardial infarction;
• Stroke;
• Diabetic nephropathy;
• Venous thromboembolism;
• Placental function disorders;
• Microcirculation and vascular tone disorders;
• Selection of drugs for hypertension;
• Smoking.
The Hypertension Susceptibility REAL-TIME PCR Genotyping Kit is an in vitro Nucleic Acid Test (NAT) – human genotyping-based product.
The Hypertension Susceptibility REAL-TIME PCR Genotyping Kit is designed to detect and discriminate nine genetic polymorphisms associated with hypertension (OMIM #145500) by real-time PCR.
The Hypertension Susceptibility REAL-TIME PCR Genotyping Kit is intended for research and diagnostic applications.
Certification: RU/IVD
| Sample | Peripheral blood |
| NA extraction | PREP-GS-GENETICS, PREP-RAPID-GENETICS |
| Sensitivity | 1 ng per amplification tube |
| Storage requirements | +2...+8 °C |
| Except of minus part of the kit | -18…-22 °С |
| Shelf life | 12 months |
|
Detection instruments |
Number of tests |
Tubes(ml)/ Strips |
Product number |
|
DT instruments (DNA-Technology) |
48 |
not pre-aliquoted |
R1-H902-N3/4EU |
