HPV SCREEN HR14(16-18-45) REAL-TIME PCR Kit

Human papillomavirus (HPV) belongs to the genus of papilloma viruses of the Papillomaviridae family and has a definitive biocycle associated with differentiation of keratinocytes. The virus infects only proliferating epithelial cells of the basal layer. Formation of viral particles occurs in the upper layers of the epithelium. Presently over 100 types of HPV are distinguished, with about 30 of them being able to infect the epithelium of a human urogenital tract.

The most frequently used test for screening of cervical cancer and precancerous changes in the epithelium is a cytological one. At the same time the diagnostic accuracy can vary depending on the specimen collection method, binding technique and smear preparation as well as a researcher’s skills. It is believed that nearly one third of cervical cancer cases are diagnosed in women who were screened regularly during cytological examination and thus false negative results for these patients were obtained. Therefore, DNA diagnostics of HPV infection is currently considered the basis for cervical cancer screening and prevention.

The fact of HPV presence can be used for adjusting an examination plan and frequency of monitoring of patient. The positive test result has high diagnostic significance for women’s age over 30. DNA diagnosis is used as a confirmatory test when detecting ASC-US (after liquid cytology and visual method) and when monitoring a therapy for CIN II, III.

The HPV SCREEN HR14(16-18-45) REAL-TIME PCR Kit is an in vitro Nucleic Acid Test (NAT) – pathogen-detection-based product.

The HPV SCREEN HR14(16-18-45) REAL-TIME PCR Kit is designed for qualitative DNA detection of fourteen

types of human papillomaviruses with high carcinogenic risk (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68 types) associated with cervical cancer, and differential detection of HPV 16, 18 and 45 types in human biological material.

The HPV SCREEN HR14(16-18-45) REAL-TIME PCR Kit is intended for research and diagnostic applications.

Certification: RU/IVD