Comparative Analysis of HPV Genotyping and Microbiome Analysis

High-risk HPV DNA detection is an effective strategy to prevent cervical cancer. Urine and vaginal self-collection methods are less invasive and widely accepted. They offer viable alternatives for women, who avoid conventional screenings due to factors like fear, cultural beliefs, physical limitations, or lack of access to healthcare facilities.

Medical scientists from ICESP (Institute of Cancer, San Paolo, Brazil) in collaboration with colleagues from other institutions conducted a comparative analysis of HPV genotyping and microbiome analysis in uterine cervix samples of patients obtained by urine, self-collection devices and health care professionals using PCR kits HPV QUANT-21 (DNA Technology) and Femoflor® Screen (DNA Technology), which are successfully used in clinical diagnostic laboratories of medical institutions and research practice worldwide.

Main conclusion of the study was that urine collection and vaginal self-sampling were the most accepted techniques. The detection of most STI, including HPV, and microbiome components, showed high concordance among the collecting strategies.

The results of the research were presented in a poster session at the 36th International Papillomavirus Conference (IPVC 2024) held in Edinburgh, UK on November 12-15, 2024.

Click here to see the poster