HLA-DQA1

The human leukocyte antigen (HLA) is a human histocompatibility gene system – a group of histocompatibility antigens. There are over 150 antigens. The locus is located on chromosome 6; it contains a large number of genes associated with the human immune system.

For diagnostic purposes HLA typing of the DRB1 gene at low resolution or at the level of 13 allele groups are the most commonly used. In most cases, the required level of typing is the allele group: 8 groups for the DQA1 gene and 12 groups for the DQB1 gene.

The difference in spouses in terms of HLA gene variants is one of the important conditions for successful beginning of pregnancy and carrying of pregnancy. The similarity in spouses in terms of HLA gene variants increases the likelihood of emergence of an embryo with a double set of identical gene variants, i.e. HLA homozygote, which is an unfavorable factor that may lead to reproductive losses. Therefore, HLA typing of spouses is used to diagnose causes of reproductive failures to identify similarities in the couple’s HLA gene variants.

HLA-DQA1 REAL-TIME PCR Genotyping Kit is intended for simultaneous detection of 8 alleles and groups of alleles of human major histocompatibility complex DQA1 gene by polymerase chain reaction.

Sample: peripheral blood

DNA extraction: PREP-GS-GENETICS and PREP-RAPID-GENETICS kits

Certification: RU/IVD